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Electrostatic Control of Glycoprotein-Surface Interactions

Electrostatic Control of Glycoprotein-Surface Interactions

Willy Menacho

Multiscale visualization of a viral spike glycoprotein interacting with a hydrophobic polarizable bilayer. The spike (green) presents three RBDs: one open (purple) and two closed (orange), surrounded by a glycan shield (red). Three glycans are highlighted: G1 (no sialic acids), G2 (one), and G3 (two). Increasing sialylation enhances electrostatic interactions (lightning features). The surface shows hydrophobic behavior with rounded water droplets.

  • Date: 05 May 2026
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